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Mosapride citrate dihydrate
CAS No. 636582-62-2
Mosapride citrate dihydrate ( AS-4370 citrate | TAK-370 )
产品货号. M15413 CAS No. 636582-62-2
Mosapride citrate (AS-4370 citrate) 是一种促胃动力剂，可作为选择性 5HT4 激动剂。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥794 | 有现货 |
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| 100MG | 获取报价 | 有现货 |
|
| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称Mosapride citrate dihydrate
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述Mosapride citrate (AS-4370 citrate) 是一种促胃动力剂，可作为选择性 5HT4 激动剂。
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产品描述Mosapride citrate (AS-4370 citrate) is a gastroprokinetic agent that acts as a selective 5HT4 agonist; accelerates gastric emptying throughout the whole of the gastrointestinal tract invivo, and is used for the treatment of gastritis, gastro-oesophageal reflux disease, functional dyspepsia and irritable bowel syndrome.Other Indication Phase 2 Clinical.
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体外实验Mosapride (0.3-30 μM) exhibits an inhibitory activity against Kv4.3 with an IC50 of 15.2 μM in a concentration-dependent manner. Mosapride also inhibits the open state of Kv4.3 currents during depolarization and accelerates the closed-state inactivation at subthreshold potentials.
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体内实验Mosapride (Intravenous injection;0.3-3 mg/kg) dose-dependently increases the antral motor activity in conscious dogs which indicates that mosapride selectively stimulates upper gastrointestinal motility. Animal Model:Beagle dogsDosage:0.3-3 mg/kgAdministration:Intravenous injection; 0.3-3 mg/kg Result:Increased the antral motor activity dose-dependently in conscious dogs.
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同义词AS-4370 citrate | TAK-370
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通路GPCR/G Protein
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靶点5-HT Receptor
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受体5-HT Receptor
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研究领域Other Indications
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适应症Other Disease
化学信息
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CAS Number636582-62-2
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分子量614.02
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分子式C27H33ClFN3O10
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纯度>98% (HPLC)
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溶解度——
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SMILESCCOC1=CC(=C(C=C1C(=O)NCC2CN(CCO2)CC3=CC=C(C=C3)F)Cl)N.C(C(=O)O)C(CC(=O)O)(C(=O)O)O.O.O
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化学全称4-Amino-5-chloro-2-ethoxy-N-[[4-[(4-fluorophenyl)methyl]morpholin-2-yl]methyl]benzamide citrate
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Kato S, et al. J Med Chem. 1991 Feb;34(2):616-24.
2. Yoshida N, et al. J Pharmacol Exp Ther. 1991 May;257(2):781-7.
3. Sakashita M, et al. Arzneimittelforschung. 1993 Aug;43(8):859-63.
产品手册
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